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Prenatal Exposure to Chemicals The U.S. is a nation built on synthetic chemicals. From furniture to paint to cleaning products to cosmetics, people are exposed on a daily basis. We all wonder how these substances, many petrochemicals derived from the oil industry, will affect our health, but never is the question more important than to an expecting mother.Prenatal chemical exposure can have lasting detrimental impacts on the lives of children.

http://www.psr.org/assets/pdfs/prenatal-exposure-to-chemicals.pdf

Why are prenatal exposures important? Prenatal chemical exposure can have lasting detrimental impacts on the lives of children. Development of the fetus in utero is the most critical time in child development because it is when the baby is just forming organ systems, growing the fastest and is the most susceptible to harm from exposure. Studies have shown that virtually all pregnant women in the U.S. have measurable levels of several toxins (phthalates, bisphenol-­‐A (BPA) and flame retardants) in their bodies that pose real threats to the development of their unborn children. These impacts can manifest in the short term as birth defects or later in life as problems with reproduction, obesity, hormones or even cancers.

Although we are using more chemicals today than ever, federal regulations do little to prevent exposure. Many birth defects and other health outcomes of toxics exposure are irreversible, so prevention, education, and strengthened regulation are vital.

How do women ingest environmental chemicals?

Chemical exposure can come from a wide variety of places and experiences. Exposure in the workplace to harmful toxins such as absorbing phthalates found in cosmetics and plastics, breathing dust or vapor from everyday products and surfaces such as sofa cushions, flooring or insecticides, and eating

foods with pesticides or toxic residue from containers are all common ways we put ourselves at risk every day.

Children vulnerabilities increase their health risks substantially. Children ingest more food and water relative to their body weight, they are constantly on the ground where contaminants collect, their defenses are not fully developed, and their high skin-­‐ to-­‐body-­‐mass ratio means they are more sponge-­‐like than adults.

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In a major research study it was found that “Major pesticides are more toxic to human cells than their declared active principles.” The study evaluated to what extent the active principle (AP) and the so-called ‘inert ingredients,’ i.e. adjuvants, in globally popular formulations account for the toxicity of 9 major pesticides: 3 herbicides, 3 insecticides, and 3 fungicides.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955666/

Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle (AP), which is the only one tested in the longest toxicological regulatory tests performed on mammals. This allows the calculation of the acceptable daily intake (ADI)—the level of exposure that is claimed to be safe for humans over the long term—and justifies the presence of residues of these pesticides at “admissible” levels in the environment and organisms. Only the AP and one metabolite are used as markers, but this does not exclude the presence of adjuvants, which are cell penetrants.”

Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles Robin Mesnage, 1 Nicolas Defarge, 1 Joël Spiroux de Vendômois, 2 and Gilles-Eric Séralini 1 ,*

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The Institute of Science in Society (ISIS) 50 page review on the harm of #GMOs is now freely available online: Ban GMOs Now due to Health & Environmental Hazards Especially in the Light of the New Genetics.

http://www.i-sis.org.uk/Ban_GMOs_Now.pdf

Bt (GMO) crops’ claim to reduce pesticide use is based on excluding the Bt produced in the crops in total ‘pesticides applied’; but the Bt toxins leach from the plants and persist in soil and water, with negative impacts on health and the ecosystem comparable to conventional pesticides. Fungicide use and insecticide treatment of corn and soybean have gone up dramatically since the introduction of Bt crops.
The breakdown of Bt traits due to target pest resistance and secondary pests has resulted in increasing use of conventional pesticides; and pesticide companies are reporting 5 to 50% increase in sales for 2012 and the first quarter of 2013.
Contrary to industry’s claim that Bt is harmless to non-target species, independent studies showed that Bt toxins elicit immune response in mammals in some cases comparable to that due to cholera toxin. This is consistent with farm workers’ reports of allergic symptoms affecting the eyes, skin and respiratory tract.
A new study found Bt proteins toxic to developing red blood cells as well as bone marrow cells in mice.
Toxicity to human kidney cells has been observed in vitro, consistent with in vivo experiments in lab animals showing toxicity to heart, kidney and liver.
Bt crops fail to control target pests due to insufficient expression of Bt toxins, thereby promoting the evolution of resistance. Bt crops promote the emergence of secondary pests when target pests are killed. Primary and secondary pests are already huge problems in the US, India and China, and are now hitting multiple crops in Brazil since Bt maize was introduced.

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Turmeric has been used in India for over 5,000 years, which is likely why still today both rural and urban populations have some of the lowest prevalence rates of Alzheimer’s disease (AD) in the world. A recent study on patients with AD found that less than a gram of turmeric daily, taken for three months, resulted in ‘remarkable improvements.’

Turmeric Produces ‘Remarkable’ Recovery in Alzheimer’s Patients by Sayer Ji,

http://www.greenmedinfo.com/blog/turmeric-produces-remarkable-recovery-alzheimers-patients Continue Reading »

Parkinson’s Disease and Pesticides – what’s the connection?
The pesticide Parkinson’s connection. What exactly causes Parkinson’s disease is far from figured out. But a clue has been lurking in cornfields for years. The data confirm it: farmers are more prone to Parkinson’s than the general population. And pesticides could be to blame. Over a decade of evidence shows a clear association between pesticide exposure and a higher risk for the second most common neurodegenerative disease, after Alzheimer’s. A new study published in Neurology proposes a potential mechanism by which at least some pesticides might contribute to Parkinson’s.

Research : Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease
Arthur G. Fitzmaurice, PhD*, Shannon L. Rhodes, PhD*, Myles Cockburn, PhD, Beate Ritz, MD, PhD and Jeff M. Bronstein, MD, PhD  http://www.neurology.org/content/82/5/419.short

The objective of the study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study.  All of the metal-coordinating dithiocarbamates tested (e.g., maneb, ziram), 2 imidazoles (benomyl, triflumizole), 2 dicarboxymides (captan, folpet), and 1 organochlorine (dieldrin) inhibited ALDH activity, potentially via metabolic byproducts (e.g., carbon disulfide, thiophosgene). Fifteen screened pesticides did not inhibit ALDH. Exposures to ALDH-inhibiting pesticides were associated with 2- to 6-fold increases in PD risk; genetic variation in ALDH2 exacerbated PD risk in subjects exposed to ALDH-inhibiting pesticides.

Conclusion: ALDH inhibition appears to be an important mechanism through which environmental toxicants contribute to PD pathogenesis, especially in genetically vulnerable individuals, suggesting several potential interventions to reduce PD occurrence or slow or reverse its progression.

Scientists find a way chemicals may contribute to Parkinson’s  By Bret Stetka

http://www.scientificamerican.com/article/parkinsons-disease-and-pesticides-whats-the-connection/

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The majority of genetically engineered crops were developed to do one thing: tolerate being sprayed with Glyphosate (the key ingredient in Monsanto’s RoundUp weedkiller), hence their trade name “RoundUp Ready.”

When these crops are fed to animals, they’re absorbing the toxic chemical at an alarming rate — according to a peer-reviewed study published in the Journal of Environmental & Analytical Toxicology just two months ago.

http://omicsonline.org/open-access/detection-of-glyphosate-residues-in-animals-and-humans-2161-0525.1000210.pdf

In the study it was found, that animals fed GMO crops (corn and soy) had much higher levels of glyphosate in their urine and organs than animals fed non-GM or organic feed.

When humans eat non-organic meat, they too are absorbing Glyphosate, as indicated in the study. Eating that corn-fed steak, unless it’s been raised organically (or strictly grass-fed) means you are eating glyphosate residues.

Given the long list of negative human health and environmental impacts of Glyphosate, it’s time you (and your family and friends) just say NO to GMO.

View a long list of studies showing all of the negative impacts of Glyphosate:
http://gmo-awareness.com/resources/glyphosate/ Continue Reading »

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Abstract CD47, a “don’t eat me” signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer

http://www.pnas.org/content/109/17/6662

http://www.pnas.org/content/suppl/2012/03/20/1121623109.DCSupplemental/pnas.201121623SI.pdf

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