Effect of Aspartame on Oxidative Stress and Monoamine Neurotransmitter Levels in Lipopolysaccharide-Treated Mice

Abridged : Neurotoxicity ResearchNeurodegeneration, Neuroregeneration, Neurotrophic Action, and Neuroprotection© Springer Science+Business Media, LLC 201110.1007/s12640-011-9264-9Omar M. E. Abdel-Salam¹  , Neveen A. Salem¹ and Jihan Seid Hussein²(1)Department of Toxicology and Narcotics, National Research Centre, Tahrir St., Dokki, Cairo, Egypt (2)Department of Medical Biochemistry, National Research Centre, Cairo, Egypt

The dipeptide aspartame (1-methyl N-L-alpha-aspartyl-Lphenylalanine) is a low-calorie sweetener that is widely used in human foods and beverages. The present study provides the evidence that the dietary sweetener aspartame increases oxidative stress in the brain of mice. In summary, findings in the present study suggest that in LPS-treated mice, aspartame significantly increases the levels of lipid peroxidation and nitrite in brain. In addition, aspartame itself impairs cellular antioxidant status because of the decreased brain levels of GSH, and glucose. Thus, aspartame increases oxidative stress in brain which could have important implications in view of the fact that oxidative stress is implicated in various brain pathologies and that the agent is one of the most widely used artificial sweeteners in human foods and drinks. Evidence is accumulating with regard to supporting an important role for oxidative stress and increased inflammatory response in the pathogenesis of several brain diseases and neurodegenerative disorders.

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Environmental factors as a cause of Crohn’s disease

Many environmental factors have  been hypothesized as causes or risk factors for Crohn’s disease.such as  diets high in sweet, fatty or refined foods may also play a role.  The disease occurs when the immune system attacks the gastrointestinal tract and for this reason, Crohn’s disease is considered an autoimmune disease. This autoimmune activity produces inflammation in the gastrointestinal tract, and therefore Crohn’s disease is classified as an inflammatory bowel disease.

 

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Big Chem, Big Harm. Low dose chemical exposure as endocrine disruptors in children

Big Chem, Big Harm?  by Nicolas Kristof NY Times
NEW research is demonstrating that some common chemicals all around us may be even more harmful than previously thought. It seems that they may damage us in ways that are transmitted generation after generation, imperiling not only us but also our descendants. Following the script of Big Tobacco a  generation ago, Big Chem has, so far, blocked any serious regulation of these endocrine disruptors, so called because they play havoc with hormones in the body’s endocrine system.

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The Autism Epidemic and Disappearing Bees: A Common Denominator?

Abridged  from article : Autism and Disappearing Bees: A Common Denominator? by Brian Moench Dr. Brian Moench is President of Utah Physicians for a Healthy Environment and a member of the Union of Concerned Scientists.Published on Monday, April 2, 2012 by Common Dreams https://www.commondreams.org/view/2012/04/02

Sources: Dr. Jim Adams, director of Arizona State University’s Autism/Asperger’s Research Program.http://autism.asu.edu

Hallmayer J, Cleveland S, Torres A, et al. “Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism,” Arch Gen Psychiatry. 2011;68(11):1095-1102. doi:10.1001/archgenpsychiatry.2011.76.Hallmayer J, Cleveland S, Torres A, et al. “Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism,” Arch Gen Psychiatry. 2011;68(11):1095-1102. doi:10.1001/archgenpsychiatry.2011.76.

C. Lu, K.M. Warchol and R.A. Callahan. “In situ replication of honey bee colony collapse disorder,” Bulletin of Insectology, Vol. 65, June 2012.  ( Source list continues below)

On a recent front page of The Salt Lake Tribune, a frightening, oversized headline read, “Highest rate in the nation, 1 in 32 Utah boys has autism.” Less well publicized, another national story ran the same day: “New pesticides linked to bee population collapse.” If you eat food and hope to do so a few years from now, this should be equally frightening. A common denominator may underlie both stories.

A recent Stanford University study, examining 192 pairs of twins, where one twin was autistic and one was not, found that genetics account for 38 percent of the risk of autism and environmental factors account for 62 percent.

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Unwanted antibiotics in our food supply- the poisoning of future generations

(NaturalHealth365) We, the consumer, can dramatically improve the health of our nation with every food purchase. In fact, it’s our responsibility to question the origin and safety of our food supply. Ultimately, we must NOT tolerate the poisoning of our food with toxic substances of any kind!

Life on this planet is at a crossroad: every single day hundreds of millions of pounds of chemicals are dumped on American soil and an estimated 13.2 million kg. of antibiotics are sold to the poultry and livestock industries, which represents 80 percent of all antibiotic sales. Does this sound healthy to you?

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Vaccine Induced Inflammation Linked To Epidemic Of Type 2 Diabetes And Metabolic Syndrome

Newly published data by Dr. J. Barthelow Classen in The Open Endocrinology Journal shows a 50% reduction of type 2 diabetes occurred in Japanese children following the discontinuation of a single vaccine, a vaccine to prevent tuberculosis. This decline occurred at a time when there is a global epidemic of type 2 diabetes and metabolic syndrome, which includes obesity, altered blood cholesterol levels, high blood pressure, and increased blood glucose resulting from insulin resistance.

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Benefits and concerns associated with biotechnology-derived foods: can additional research reduce children health risks?

Genetically modified foods pose unique new health risks for children with food allergy.

The development of techniques devised for the genetic manipulation of foods poses new risks for children with food allergy (FA). The introduction of foreign allergenic proteins from different foods into previously tolerated foods may trigger allergic reactions, often complicating with anaphylactic shock in a subset of allergic babies. Children with FA, even if subjected to preventative diets, always challenge the risk of developing allergic manifestations after unintentional intake of a non tolerated food in restaurant settings, with relatives or schoolmates, etc, where product labeling is necessarily lacking. The introduction of potentially allergenic proteins into foods generally considered safe for allergic children can be done deliberately, by either substantially altering the food ingredients, or by genetic manipulation which change the composition or transfer allergens, or unintentionally by quality control failures, due to contamination in the production process, or to genetic mis-manipulation. There is a controversy between multinationals often favored by governments and consumer association resistance, thus an equidistant analysis poses some unprecedented impediments. The importance of FA and the potential of transgenic plants to bring food allergens into the food supply should not be disregarded. The expression in soybeans of a Brazil nut protein resulted in a food allergen ex-pressed in widely used infant formulas, so paving the way to an often reported multinational debacle. Genetic engineering poses innovative ethical and social concerns, as well as serious challenges to the environment, human health, animal welfare, and the future of agriculture. In this paper will be emphasized practical concepts more crucial for pediatricians.

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Wheat or Dairy- TRIGR of Juvenile Diabetes -in study called TEDDY, The Environmental Determination of Diabetes in Young

As far as diabetes is concerned the early onset is scientifically named in the landmark study called TEDDY, or The Environmental Determination of Diabetes in the young
Principal TRIGRS are dairy and or wheat products given to a child at too young an age a ‘window of vulnerability” and auto immune reaction occurs
Wheat seed is modified by GMO to contain BT a bacillus with pesticidal properties courtesy of bio technology and dairy has rbgh hormones given to dairy producing cows to accelerate milk production
We need far more human clinical trials in the US to determine if these activties should be abolished as part of the Precautionary Principle to protect our children– a constitutional amendment making the precautionary principle a basic human right for our children
Here is speech given by Ed Rosenthal as Chair of the Walk to Cure Juvenile Diabetes in 2007 on the research to find a cure for Juvenile Diabetes.
Note the comments referencing Baby-DIAB and the TEDDY Study, The Environmental Determination of Diabetes in the young– dairy and wheat are trigrs.

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The Environmental Determinants of Diabetes in the Young (TEDDY) Study

The Environmental Determinants of Diabetes in the Young (TEDDY) Study
What is the purpose of TEDDY?
The TEDDY study – T he E nvironmental D eterminants of D iabetes in the Y oung – is looking for the causes of type 1 diabetes mellitus (T1DM). T1DM used to be called childhood diabetes or insulin-dependent diabetes. T1DM occurs when special cells in the body, called the beta cells of the pancreas, are destroyed by the body’s infection fighting cells, called immune cells. When these beta cells are destroyed, the body cannot make the chemical insulin. Insulin is needed for the body to use food. Insulin helps keep the sugar level in the blood normal. If there is no insulin in the body, the sugar in the blood becomes high and this makes someone sick. Children with type 1 diabetes must take insulin shots and monitor their blood sugar levels several times a day to stay alive and healthy.
Research tells us that children who get diabetes have certain kind of genes. Other children who have these genes are at higher risk for getting diabetes. However, not all children who are higher risk get diabetes. We think that something happens that “triggers” or causes a child with higher risk genes to actually get diabetes. It is the purpose of this study to try and find out what are the triggers that cause children to get diabetes.
Who is doing TEDDY?
Six groups of research doctors from across the world are working together in this study. All of the centers are following children with higher risk genes. All of the centers are going to get the same information about the lives of the children in the study.

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