Archive for August, 2013

Published in the Journal of Natural Products in 1996, Compound 1, one of five extracted from the seed of the graviola fruit, was found to be “selectively cytotoxic to colon adenocarcinoma cells (HT-29) in which it was 10,000 times the potency of adriamycin.” 

Given these findings the time may be ripe for reconsideration of graviola in the prevention and/or treatment of cancers, such as colon and breast cancer.

Post by  Sayer Ji  the founder and chair of GreenMedInfo.com whose  writings have been published in the Wellbeing Journal, the Journal of Gluten Sensitivity) (more…)


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AboveTheFolds daily newsletters on environmental issues are an excellent source.
by Environmental Health Scienceswww.EnvironmentalHealthNews.org

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Here are some prior stories

Avian flu,Climate, Children’s health, Air pollution, Cancer, Reproductive disorders, Endocrine disruption, Birth defects, Learning and developmental disabilities, Immune disorders, Environmental justice, Superfund, Water treatment/sewage, Food safety, Integrity of science, Green chemistry.

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by CAREY GILLAM Reuters Published Wednesday, Aug. 28 2013


Researchers in the key corn-growing state of Illinois are finding significant damage from rootworms in farm fields planted in a rotation with a genetically modified corn, a combination of measures that are supposed to protect the crop from the pests, according to a new report.

“It’s very alarming,” said Joe Spencer, an insect behaviorist with the Illinois Natural History Survey who is researching the issue. (more…)

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New study suggests “universal fetal exposure” to BPA

Aug 23, 2013
Gerona, RR, TJ Woodruff, CA Dickenson, J Pan, JM Schwartz, S Sen, M Friesen, VY Fujimoto and PA Hunt. 2013. BPA, BPA glucuronide, and BPA sulfate in mid-gestation umbilical cord serum in a northern California cohort. Environmental Science and Technology http://dx.doi.org/10.1021/es402764

A new study in California found bisphenol A in all samples of umbilical cord blood obtained from pregnant women, suggesting universal fetal exposure. More than one-third of the samples had levels comparable to or higher than levels associated with health effects in animals. (more…)

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Lifetime Pesticide Use and Telomere Shortening among Male Pesticide Applicators in the Agricultural Health StudyLifang Hou,1,2 Gabriella Andreotti,3 Andrea A. Baccarelli,4 Sharon Savage,3 Jane A. Hoppin,5 Dale P. Sandler,5 Joseph Barker,6 Zhong-Zheng Zhu,7 Mirjam Hoxha,8,9 Laura Dioni,8,9 Xiao Zhang,1 Stella Koutros,3 Laura E. Beane Freeman,3and Michael C. Alavanja3  

Background: Telomere length (TL) in surrogate tissues may be influenced by environmental exposures. http://ehp.niehs.nih.gov/1206432/

Objective: We aimed to determine whether lifetime pesticides use is associated with buccal cell TL.

Methods: We examined buccal cell TL in relation to lifetime use of 48 pesticides for 1,234 cancer-free white male pesticide applicators in the Agricultural Health Study (AHS), a prospective cohort study of 57,310 licensed pesticide applicators. Participants provided detailed information on lifetime use of 50 pesticides at enrollment (1993–1997). Buccal cells were collected from 1999 to 2006. Relative telomere length (RTL) was measured using quantitative real-time polymerase chain reaction. We used linear regression modeling to evaluate the associations between specific pesticides and the logarithm of RTL, adjusting for age at buccal cell collection, state of residence, applicator license type, chewing tobacco use, and total lifetime days of all pesticide use

Results: The mean RTL for participants decreased significantly in association with increased lifetime days of pesticide use for alachlor (p = 0.002), 2,4-dichlorophenoxyacetic acid (2,4-D; p = 0.004), metolachlor (p = 0.01), trifluralin (p = 0.05), permethrin (for animal application) (p = 0.02), and toxaphene (p = 0.04). A similar pattern of RTL shortening was observed with the metric lifetime intensity-weighted days of pesticide use. For dichlorodiphenyltrichloroethane (DDT), we observed significant RTL shortening for lifetime intensity-weighted days (p = 0.04), but not for lifetime days of DDT use (p = 0.08). No significant RTL lengthening was observed for any pesticide.

Conclusion: Seven pesticides previously associated with cancer risk in the epidemiologic literature were inversely associated with RTL in buccal cell DNA among cancer-free pesticide applicators. Replication of these findings is needed because we cannot rule out chance or fully rule out bias. (more…)

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Food Chem Toxicol. 2013 Jun 10;59C:129-136. doi: 10.1016/j.fct.2013.05.057. [Epub ahead of print]
Glyphosate induces human breast cancer cells growth via estrogen receptors. Thongprakaisang SThiantanawat ARangkadilok NSuriyo TSatayavivad J.

Source http://www.ncbi.nlm.nih.gov/pubmed/23756170

Environmental Toxicology Program, Chulabhorn Graduate Institute, Kamphaengphet 6 Road, Laksi, Bangkok 10210, Thailand.

Abstract : Glyphosate is an active ingredient of the most widely used herbicide and it is believed to be less toxic than other pesticides. However, several recent studies showed its potential adverse health effects to humans as it may be an endocrine disruptor. This study focuses on the effects of pure glyphosate on estrogen receptors (ERs) mediated transcriptional activity and their expressions. Glyphosate exerted proliferative effects only in human hormone-dependent breast cancer, T47D cells, but not in hormone-independent breast cancer, MDA-MB231 cells, at 10-12 to 10-6M in estrogen withdrawal condition. The proliferative concentrations of glyphosate that induced the activation of estrogen response element (ERE) transcription activity were 5-13 fold of control in T47D-KBluc cells and this activation was inhibited by an estrogen antagonist, ICI 182780, indicating that the estrogenic activity of glyphosate was mediated via ERs. Furthermore, glyphosate also altered both ERα and β expression. These results indicated that low and environmentally relevant concentrations of glyphosate possessed estrogenic activity. Glyphosate-based herbicides are widely used for soybean cultivation, and our results also found that there was an additive estrogenic effect between glyphosate and genistein, a phytoestrogen in soybeans. However, these additive effects of glyphosate contamination in soybeans need further animal study.

Copyright © 2013 Elsevier Ltd. All rights reserved.

For another study on Glysophate http://www.for.gov.bc.ca/hfp/publications/00015/6-Dost-Glyphosate.pdf

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EPA stop lowballing the link between atrazine & cancer

Atrazine is widely found in drinking water.Scientists are concerned

EPA’s science advisors urged the agency to rethink its conclusions on atrazine & cancer.

Tell the agency to listen.

Take Action

Atrazine is found in most of our water — about 94%, according to government sampling. And this month, EPA officials start taking another look at the health and environmental harms of Syngenta’s flagship herbicide.

With exposure so widespread, it’s hugely important that they get it right.

Listen up, EPA» According to its own scientific advisory panel, EPA is underestimating the cancer risks of atrazine — including risks of childhood cancer. The panel also expressed concern about reproductive harms and birth defects that have been linked to low-level exposure. Join us in urging EPA to listen to their scientists.

When atrazine was last up for review 10 years ago, Syngenta reps held more than 50 closed-door meetings with EPA officials. And the same month the herbicide got the green light for continued widespread use in the U.S., the European Union announced a ban due to “unpreventable water contamination” and concerns about human health effects.

We can’t let this happen again.

Follow the science» Evidence that atrazine can harm human health has only gotten stronger since EPA’s last review. Meanwhile, Syngenta continues its aggressive campaign to protect and promote its flagship product. Let’s be sure that this time around, EPA listens to the independent scientists.

Thanks so much for taking action.

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