The Physics of Life, Evolution and the Endocannabinoid System by Dr Bob Melamede Program Director Phoenix Tears Foundation, Denver CO,
The earth is constantly bombarded by electromagnetic waves that in conjunction with the heat of the earth have powered the chemical conversions that led to the emergence of life. Nobel laureate Ilya Prigogine pioneered a new form of physics known is far from equilibrium thermodynamics. His work is based on the concept that flowing energy naturally organizes matter. Flow dependent dissipative structures naturally form because they generate more entropy to their surroundings than would occur in their absence. Hence they are consistent with the second law of thermodynamics. Consequently, for the first time in human history, we have a theoretical framework for understanding life, its emergence and it’s evolution.
The emergence of life from the inorganic prebiotic “soup” was a far from equilibrium phase change, as was/is also the case with the emergence of new species or their disappearance with extinction. With the evolution of vertebrates, a new homeostatic mechanism appeared, the endocannabinoid system. The endocannabinoid system homeostatically regulates all human body systems (circulatory, digestive, endocrine, immunological, neuromuscular, skeletal, reproductive and skin) from conception until death!
The CB1 receptor, responsible for the euphoric effects of cannabis, regulates free radical production by regulating ion channels, in particular calcium. Consequently, they control all forms of energy-requiring cell activation, i.e., muscle contraction, nerve conduction, endocrine hormone production, etc., essentially cell differentiation as they drove the evolution of the human brain. Additionally, free radical are critical determinants of the various the forms of cell death. The probability of cell death, apoptosis or necrosis (including numerous subdivisions), is ultimately determined by the destructive free radicals that are natural metabolically produced or brought into the system fro outside: sunlight and all forms electromagnetic radiation to which life is constantly exposed.
The CB1 receptor is found everywhere, and composes most abundant neurotransmitter system in the human brain (not taught in medical schools). It allows for the fine -tuning of energy production via the dangerous, but efficient free radical producing electron transport system, As a result, the CB1 receptor has facilitated the development of the human brain, characterized by complexity and hence, distance from equilibrium. All cellular differentiation is promoted by efficient energy production.
The CB2 receptor activation turns on beta-oxidation of fats and makes energy inefficiently but safely. Concomitant with fat burning, cells initiate autophagy, a recycling mechanism by which cells eat their free radical damaged components and recycle them. Fat burning cells become less differentiated as they try to repair themselves. Drug resistance cancer cells and their metastasis are possible consequences. By regulating the fuel source, and hence differentiation state of cells, they can be made more or less susceptible to dying. Consequently, cancers, infections (especially viral), and the aging process itself, can be regulated by manipulating energy flow, and hence free radical production with cannabinoids.
Both scientifically and experientially, human suffering can be dramatically reduced through the consumption of the essential nutrient, our sacrament, high THC containing cannabis extract-the oil of life. Appendix II provides the references for the science that is assembled into Appendix III. In accordance with the Declaration of Human Rights (see Appendix IV) Jason must be released, and his medicine must be returned to the patients for whom it was destined in accordance with their Fundamental Human Rights..
Evolutionism Surprisingly, evolution has selected for marijuana-like compounds to play a critical role in maintaining human health. The appropriate use of marijuana promotes human health. Hence, its appropriate use is thus mandated by Evolutionism since evolutionists strive to do what scientific facts suggest is healthy for themselves, their family, their community, their country and their planet. Currently, we are deprived of our religious freedom. We cannot practice our fact -based religion because people of other, typically faith -based, religions deny the truth about this unique plant, and make laws contrary to fact despite its use as a component of the Holy Anointing oil specifically described the Bible. Because we faithfully adhere to our religious principles, I are labeled as criminals!
All people make marijuana-like compounds known as endocannabinoids. Whenever anyone gets hungry, they are giving themselves the “munchies” with the cannabinoids that they produce. In fact, cannabinoids control every system in the human body (cardiovascular, nervous, endocrine, immune, digestive, reproductive, excretory, musculo-sketetal). It is because of their all-pervasive activity that cannabinoids can impact on so many illnesses. Cannabinoids: kill many types of cancer cells, protect against Alzheimer’s disease, delay the onset and severity of auto-immune diseases such as arthritis, diabetes, multiple sclerosis and Crohn’s disease, and recently has been shown to both protect the heart from damage as well as to protect against, arteriosclerosis, they relieve pain, stimulate the appetite and promote sound sleep. Cannabinoids also regulate stress, learning and open-mindedness. Hence, we can predict that many followers of faith-based religions are deficient in cannabinoid activity, and are impaired in their capacity for open-mindedness. As a result, they make laws that are contrary to fact and freedom.
Far from equilibrium thermodynamics, as pioneered by Nobel Laureate Illya Prigogine, shows that flowing energy intrinsically has a creative capacity. This physical reality has manifested itself as chemical evolution, life and consciousness As such, these principles constitute the foundation of a belief in an abstract higher creative force that has parallels with other religious beliefs (GOD=generalized open system dynamics). These concepts are of particular interest to a growing number of people in a broad spectrum of fields, in particular those devoted personal growth, health, and the exploration of their minds. The principles of evolutionism provide a foundation, based on sound scientific principles for viewing life in a positive, and constructive manner. On the other hand they provide a unifying framework to challenge current laws that squander our resources and unconstitutionally restrict our basic human rights including religious freedom.
What does this mean from a practical point of view? It is a personal search for an evolving understanding and application of the principles under discussion. It requires lifelong learning. This process becomes a fulltime perspective as one applies and refines the simple concept of moving further from equilibrium to all aspects of ones existence. Our life’s energy becomes more functionally applied as less energy is wasted on primitive nonfunctional organized structures that waste life’s potential. All things that healthy individuals in a healthy society value conform to the paradigm that there is value in the move from equilibrium. Our planet, its ecosystems, nations, communities, families all evolve by these principles.
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