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Archive for the ‘Endocrine Disruption’ Category

A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States ” the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878266/
David A Geier, Brian S Hooker,  Janet K Kern, Paul G King, Lisa K Sykes, and Mark R Geier

Results In phase I, it was observed that there was a significantly increased risk ratio for the incidence of ASD reported following the Thimerosal-containing DTaP vaccine in comparison to the Thimerosal-free DTaP vaccine. In phase II, it was observed that cases diagnosed with an ASD were significantly more likely than controls to receive increased organic-Hg from Thimerosal-containing hepatitis B vaccine administered within the first, second, and sixth month of life.

Conclusions: Routine childhood vaccination is an important public health tool to reduce the morbidity and mortality associated with infectious diseases, but the present study provides new epidemiological evidence supporting an association between increasing organic-Hg exposure from Thimerosal-containing childhood vaccines and the subsequent risk of an ASD diagnosis.

Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns of behavior, interests, and activities. A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills, which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after birth. To date, the etiology of ASD remains under debate, however, many studies suggest toxicity, especially from mercury (Hg), in individuals diagnosed with an ASD. The present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal (49.55% Hg by weight) in childhood vaccines by conducting a two-phased (hypothesis generating/hypothesis testing) study with documented exposure to varying levels of Thimerosal from vaccinations. (more…)

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Autism: a novel form of mercury poisoning

https://www.ncbi.nlm.nih.gov/pubmed/11339848/

Autism: a novel form of mercury poisoning. Bernard S1, Enayati A, Redwood L, Roger H, Binstock T.
Autism is a syndrome characterized by impairments in social relatedness and communication, repetitive behaviors, abnormal movements, and sensory dysfunction

A review of medical literature and US government data suggests that: (i) many cases of idiopathic autism are induced by early mercury exposure from thimerosal which is found in vaccines given to young children  (more…)

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Twenty-Five Years of Endocrine Disruption Science: Remembering Theo Colborn  http://ehp.niehs.nih.gov/ehp746/

For nearly 30 years, Dr. Theo Colborn (1927–2014) dedicated herself to studying the harmful effects of endocrine-disrupting chemicals on wildlife, humans, and the environment. More recently, she extended this effort to address the health impacts of unconventional oil and gas development. Colborn was a visionary leader who excelled at synthesizing scientific findings across disciplines. Using her unique insights and strong moral convictions, she changed the face of toxicological research, influenced chemical regulatory policy, and educated the public. In 2003, Colborn started a nonprofit organization—The Endocrine Disruption Exchange (TEDX). As we celebrate the 25th anniversary of endocrine disruption science, TEDX continues her legacy of analyzing the extensive body of environmental health research and developing unique educational resources to support public policy and education. Among other tools, TEDX currently uses the systematic review framework developed by the National Toxicology Program at the National Institute of Environmental Health Sciences, to answer research questions of pressing concern. In this article, we pay homage to the tenacious woman and the exemplary contribution she made to the field of environmental health. Recommendations for the future of the field are drawn from her wisdom. (more…)

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

http://www.nature.com/nature/journal/v537/n7618/full/nature19323.html

Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ. In a transgenic mouse model of AD, aducanumab is shown to enter the brain, bind parenchymal Aβ, and reduce soluble and insoluble Aβ in a dose-dependent manner. In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner. This is accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores. The main safety and tolerability findings are amyloid-related imaging abnormalities. These results justify further development of aducanumab for the treatment of AD. Should the slowing of clinical decline be confirmed in ongoing phase 3 clinical trials, it would provide compelling support for the amyloid hypothesis.

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At Community Day School in Sarasota, Florida the Precautionary Principle was adopted by the schools board of directors. As a result no chemical pesticides are used in the school’s Papa Ed and Mimi Sustainable Garden or on the campus. Advocating the Precautionary Principle means to hold the pesticide accountable and  no pesticide or any chemical can be used around children unless the pesticide is PROVEN safe first not relatively safe but completely harmless.

The Precautionary Principle and the Community Day School adopting of APP flies in the face of the chemical pesticide industry which is protected by the pseudo science of ” relative toxicity” in which chemical pesticides are registered for use by and on its” relative safety.” This is pseudo science since the pesticides relative safety is determined by regulatory on its LD 50.

So what is an LD 50 that determines a pesticides relative safety ? An LD50  is the amount of the pesticide (the Lethal Dose) that kills 50% of the lab animals tested. Therefore according to the tenets of relative toxicity (or safety) the pesticide with the lowest amount of chemical that kills the 50 % of lab animals ( LD50 Lethal Dose) the relative toxicity is greater than a chemical which kills the 50% of lab animals with a lesser amount.Therefore the chemical which uses a greater amount that kills the same 50% of lab animals is RELATIVE SAFER. What a crock!  Now if you do not pause and consider that bizarre enough remember the testing is only on the 50% killed by the lethal dose, but what about the surviving 50% what conditions did those animals suffer. There is no data no testing no reporting required on the 50% of surviving animals. And that is all we have as a nation to protect our children from damage due to pesticides exposure.

Comments Sarah Catherine Leithauser-French on pesticide registration and the LD 50 registration ” With all the false labelling hiding GMOS in food & drink under natural sounding words. Surely not a funny jokes to the millions with GI issues, allergies, nervous system, neurological & other maladies already. Unconscionable. Opposite of the Golden Rule. Plus arrogantly, and without apology.What about their own children, relatives, grandchildren, or friends? I can’t understand it at all.”

Four in five U.S. children are exposed to organophosphate pesticides, mostly from food. (Though several studies have also linked organophosphate exposure in pregnant women and children to residential insecticide use in urban areas, where indoor pest control is common.) In addition to pesticides, almost all children also carry levels of lead, mercury, the plastics additive bisphenol A, flame retardants, and dozens of other untested chemicals in their bodies. (more…)

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UCLA study finds advanced thyroid cancer rate in some California counties is well above national averageTo investigate the possibility of environmental impacts as a predisposition for thyroid cancer, we sought to identify counties in California with possible geographic clustering of advanced thyroid cancer cases. We recently published our findings in the Journal of Surgical Research. – See more at: http://www.journalofsurgicalresearch.com/article/S0022-4804(15)01062-8/abstract

The research was led by Dr. Avital Harari, a member of the UCLA Jonsson Comprehensive Cancer Center and assistant professor of surgery.

Approximately 63,000 people were diagnosed with thyroid cancer nationwide last year, and according to the National Cancer Institute, the incidence of thyroid cancer has increased across racial, ethnic and gender lines over the past several decades. When detected early, thyroid cancer is treatable and even curable. However, survival rates are much lower for people who are diagnosed at advanced stages of the disease.

(more…)

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Project TENDR: “Targeting Environmental Neuro-Developmental Risks,”

A Call to Action to Prevent Neurodevelopmental Harm from Environmental Chemicals

A new alliance of leading scientists, medical experts, and children’s health advocates, including TEDX, are calling for immediate action to address the growing problem of neurodevelopmental disorders attributable to toxic chemical exposure.

We believe the increasing risk of children having intellectual and learning disabilities, autism spectrum disorder, attention deficits, hyperactivity, and other maladaptive behaviors is unacceptable.

There is ample scientific evidence to support a link between children’s risks for neurodevelopmental disorders and toxic chemicals in consumer products, food, air and water. Prime examples include certain pesticides, flame retardants, combustion related air pollutants, lead, mercury and PCBs.

Project TENDR, which stands for “Targeting Environmental Neuro-Developmental Risks,” is calling for immediate government action to reduce sources of exposure – by requiring removal of neurotoxic chemicals from food and consumer products, cleaning up environmental sources, and regulating industrial processes. Government agencies must also prevent exposure by improving assessment of neurodevelopmental harm. We are calling on businesses to eliminate such chemicals from supply chains and products, and urging health professionals to address environmental chemicals in patient care and public health practice.

Go to the Project TENDR website to read the published consensus statement, see authors, supporting organizations and societies, read chemical and pollutant summaries, and learn what individuals can do to protect their families.

Announcing Project TENDR

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