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Archive for the ‘National Cancer Insitute PCP Report- Reducing Environmental Cancer Risk’ Category

What Killed Jack McCall?
A California Farmer Dies and a Case Against Monsanto Takes Root

California farmer Jack McCall, used Monsanto Roundup [glyphosate] on his 20-acre fruit and vegetable farm for nearly 30 years. When he stopped using Roundup after learning of glyphosate’s link to cancer, McCall had already developed cancer symptoms.

On December 26, 2015, Jack McCall passed away after suffering a massive stroke due to complications from a rare version of non-Hodgkin lymphoma. His widow, Teri McCall has filed a wrongful death lawsuit against Monsanto, claiming exposure to Roundup caused her late husband to develop cancer. The lawsuit further alleges that Monsanto purposely downplayed the cancer risk associated with Roundup exposure.

So far, more than 900 people across the United States, who have been diagnosed with non-Hodgkin lymphoma, have sued Monsanto. Thousands more have hired attorneys and their lawsuits will be filed in due time.

Monsanto Roundup Lawsuit  https://www.baumhedlundlaw.com/toxic-tort-law/monsanto-roundup-lawsuit/

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Cannabinoids and gliomas. Velasco G, Carracedo A, Blázquez C, Lorente M, Aguado T, Haro A, Sánchez C, Galve-Roperh I, Guzmán M. https://www.ncbi.nlm.nih.gov/pubmed/17952650

Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances–the endocannabinoids–that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor cells, including glioma cells, in laboratory animals.

They do so by modulating key cell signaling pathways, mostly the endoplasmic reticulum stress response, thereby inducing antitumoral actions such as the apoptotic death of tumor cells and the inhibition of tumor angiogenesis. Of interest, cannabinoids seem to be selective antitumoral compounds, as they kill glioma cells, but not their non-transformed astroglial counterparts.

On the basis of these preclinical findings, a pilot clinical study of Delta(9)-tetrahydrocannabinol (THC) in patients with recurrent glioblastoma multiforme has been recently run. The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids.

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Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.
Gupta P1, Wright SE2, Kim SH3, Srivastava SK4. https://www.ncbi.nlm.nih.gov/pubmed/25152445
Abstract
The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present. Phenethyl isothiocyanate (PEITC) is present as gluconasturtiin in many cruciferous vegetables with remarkable anti-cancer effects. PEITC is known to not only prevent the initiation phase of carcinogenesis process but also to inhibit the progression of tumorigenesis. PEITC targets multiple proteins to suppress various cancer-promoting mechanisms such as cell proliferation, progression and metastasis. Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. Based on accumulating evidence, PEITC appears to be a promising agent for cancer therapy and is already under clinical trials for leukemia and lung cancer. This is the first review which provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of PEITC as a future anti-cancer agent.
Copyright © 2014 Elsevier B.V. All rights reserved.

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Mainstream medicine’s cancer treatments of radiation and chemotherapy are far from a cure. In fact, they make cancer more deadly. But new research shows some common vegetables may be more effective in battling cancer.

http://www.greenmedinfo.com/blog/cabbage-beats-chemo-cervical-cancer-2?page=1

http://www.greenmedinfo.com/blog/cabbage-beats-chemo-cervical-cancer-2

By: Margie King, Health Coach copyrighted by GreenMedInfo LLC, 2015

Now researchers from South Dakota State University have found that a compound in cruciferous vegetables like broccoli, cabbage, and cauliflower may target those cancer stem cells. [ii] In fact, it may help prevent the recurrence and spread of some cancers.

The compound is called phenethyl isothiocyanate (PEITC). When the researchers added PEITC to a Petri dish with human cervical cancer stem cells about 75 percent of the stem cells died within 24 hours.

PEITC is found in cruciferous vegetables. Studies show it has anti-inflammatory powers. It’s also been shown to have chemopreventive activity against a range of cancers including colon, prostate, breast, cervical, ovarian, and pancreatic. It’s currently in clinical trials for lung cancer.

The South Dakota researchers found that PEITC slowed the formation of cervical cancer stem cells in a dose-dependent manner. The researchers also found that PEITC significantly reduced the proliferation of both cervical cancer cells and stem cells. In fact, it worked comparably to salinomycin, a chemo drug, but without the toxic side effects.

Why? The answer has to do with cancer stem cells (CSCs) that chemo and radiation can’t touch. (more…)

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Household Chemical Exposures and the Risk of Canine Malignant Lymphoma, a Model for Human Non-Hodgkin’s Lymphoma

In summary, findings of this study suggest that exposure to certain types of lawn care chemicals may increase the risk of malignant lymphoma in dogs. Additional studies are needed to further evaluate the effects of specific chemical components of lawn care products on risk of canine malignant lymphoma, and may potentially contribute to human NHL as well.

Lawn Chemicals Linked to 2 Types of Cancer in Dogs

According to a study conducted over a 6 year period at the Foster Hospital for Small Animals at Tufts University’s Cummings School of Veterinary Medicine, exposure to lawn pesticides, specifically those applied by professional lawn care companies, raised the risk of canine malignant lymphoma (CML) by as much as 70%

Epidemiologic studies of companion animals offer an important opportunity to identify risk factors for cancers in animals and humans. Canine malignant lymphoma (CML) has been established as a model for non-Hodgkin’s lymphoma (NHL). Previous studies have suggested that exposure to environmental chemicals may relate to development of CML.

Methods We assessed the relation of exposure to flea and tick control products and lawn-care products and risk of CML in a case-control study of dogs presented to a tertiary-care veterinary hospital (2000–2006). Cases were 263 dogs with biopsy-confirmed CML. Controls included 240 dogs with benign tumors and 230 dogs undergoing surgeries unrelated to cancer. Dog owners completed a 10-page questionnaire measuring demographic, environmental, and medical factors.

Results After adjustment for age, weight, and other factors, use of specific lawn care products was associated with greater risk of CML. Specifically, the use of professionally applied pesticides was associated with a significant 70% higher risk of CML (odds ratio(OR)=1.7; 95% confidence interval (CI)=1.1–2.7). Risk was also higher in those reporting use of self-applied insect growth regulators (OR = 2.7; 95% CI=1.1–6.8). The use of flea and tick control products was unrelated to risk of CML.

Conclusions Results suggest that use of some lawn care chemicals may increase the risk of CML. Additional analyses are needed to evaluate whether specific chemicals in these products may be related to risk of CML, and perhaps to human NHL as well. (more…)

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Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer. ACS Nano, 2016; DOI: 10.1021/acsnano.6b00320

Math, biology and nanotechnology are becoming strange, yet effective bed-fellows in the fight against cancer treatment resistance. Researchers have engineered a revolutionary new approach to cancer treatment that pits a lethal combination of drugs together into a single nano particle.

Math, biology and nanotechnology are becoming strange, yet effective bed-fellows in the fight against cancer treatment resistance. Researchers at the University of Waterloo and Harvard Medical School have engineered a revolutionary new approach to cancer treatment that pits a lethal combination of drugs together into a single nanoparticle. The approach the bioengineers took was to build a single nanoparticle, inspired by computer models, that exploit a technique known as supramolecular chemistry. This nanotechnology enables scientists to build cholesterol-tethered drugs together from “tetris-like” building blocks that self-assemble, incorporating multiple drugs into stable, individual nano-vehicles that target tumors through the leaky vasculature. This 2-in-1 strategy ensures that resistance to therapy never has a chance to develop, bringing together the right recipe to destroy surviving cancer cells. https://www.sciencedaily.com/releases/2016/06/160623150159.htm

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With the epidemic of disease continuously wrought on to children in 2016 with a root cause of exposure to toxic chemicals in the environment it is time to remind ourselves of the importance of the research publication called the Presidents Cancer Panel Study 2010. This research is so critical for the health of our children and grandchildren. The research examines the impact of environmental factors on cancer and is subtitled “Reducing Environmental Cancer Risk, what we can do now.”

We must practice the Precautionary Principle when using chemical pesticides and children are present or will be playing in the area.

Click below to read the Presidents Cancer Panel Study 2010 ,which examines the impact of environmental factors on cancer and is subtitled “Reducing Environmental Cancer Risk, what we can do now.”

We need a regulatory approach to children’s health eliminating potential hazards without accepting a level of harm. Chemical companies must prove that their products will have no adverse effect on children’s health before the chemical is approved for use by EPA.

President’s Cancer Panel (PCP) -REDUCING ENVIRONMENTAL CANCER RISK What We Can Do Now THIS IS PEER REVIEWED PUBLISHED SCIENCE WHICH LINKS CHEMICAL EXPOSURE AND CHILDHOOD DISEASE AND IS ADDRESSED IN THE PUBLICATION OF THE PRESIDENTS OF THE UNITED STATES CANCER PANEL STUDY (PCP)

NATIONAL CANCER INSTITUTE REPORT- REDUCING ENVIRONMENTAL CANCER RISK – WHAT WE CAN DO NOW

http://deainfo.nci.nih.gov/advisory/pcp/annualReports/pcp08-09rpt/PCP_Report_08-09_508.pdf

WHEN YOU READ THE VOLUME OF RESEARCH YOURSELF, YOU WILL UNDERSTAND WHY THE SCIENTISTS STATE IN THE PCP ”GRIEVOUS HARM” TO CHILDREN FROM EXPOSURE HAS NOT BEEN ADDRESSED BY APPROPRIATE ACTION
PLEASE STOP THE USE OF PESTICIDES HERBICIDES OR FUNGISCIDES WHERE AND WHEN CHILDREN ARE PRESENT. THE SCIENCE IS INCONTROVERTIBLE . DEMAND THE USE OF NON TOXIC ALTERNATIVES

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