Archive for the ‘Safe Chemicals Act’ Category

Here’s an article from our local paper on contaminated drinking water around the state and the country.  Scroll down to the EWG “data base” and click.  Enter your zip code and it will tell you how healthy or contaminated your drinking water is.  And will list the chemicals.  Was rather shocked to see that my area had 6 contaminants listed … all cancer-causing …
Next thing I’ll be doing is to look into the type of water filter I have (I bought a pretty good one a year ago), and see if it filters out the chemicals listed.

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Pesticide Exposure found to cause Parkinsons Disease as Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease


The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study.

Methods: A novel ex vivo assay was developed to identify pesticides that can inhibit neuronal ALDH activity. These were investigated for PD associations in a population-based case-control study, the Parkinson’s Environment & Genes (PEG) Study. Common variants in the mitochondrial ALDH2 gene were genotyped to assess effect measure modification (statistical interaction) of the pesticide effects by genetic variation.

Results: All of the metal-coordinating dithiocarbamates tested (e.g., maneb, ziram), 2 imidazoles (benomyl, triflumizole), 2 dicarboxymides (captan, folpet), and 1 organochlorine (dieldrin) inhibited ALDH activity, potentially via metabolic byproducts (e.g., carbon disulfide, thiophosgene). Fifteen screened pesticides did not inhibit ALDH. Exposures to ALDH-inhibiting pesticides were associated with 2- to 6-fold increases in PD risk; genetic variation in ALDH2 exacerbated PD risk in subjects exposed to ALDH-inhibiting pesticides.

Conclusion: ALDH inhibition appears to be an important mechanism through which environmental toxicants contribute to PD pathogenesis, especially in genetically vulnerable individuals, suggesting several potential interventions to reduce PD occurrence or slow or reverse its progression.


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Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles

Robin Mesnage, 1 Nicolas Defarge, 1 Joël Spiroux de Vendômois, 2 and Gilles-Eric Séralini


Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle, which is usually tested alone.The chronic tests of pesticides may not reflect relevant environmental exposures if only one ingredient is tested alone. (more…)

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Unhealthy schools are a threat to public health and an injustice to children. Ninety-eight percent of all school-aged children attend school. Other than home, schools are the environment where children spend the most time. Yet tens of thousands of P-12 school buildings are dirty, polluted, or decayed. Many are sited on or too close to hazards. As a result, school environments leave the most vulnerable learners at risk of or with suspected exposures that no agency addresses.   (more…)

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Humans are exposed to multiple chemicals at a time in a myriad of conditions at all stages of our lives. For example, workers and those living near polluting facilities likely encounter higher exposures than individuals working and living in less polluted settings. Similarly, young children, pregnant women, and others likely have vulnerabilities that our current toxicity testing does not take into account. It has been 37 years since Congress passed the Toxic Substances Control Act (TSCA) which was intended to ensure the safety of industrial chemicals (more…)

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EPA is currently addressing the challenge of updating its hazardous chemical assessment approaches.  Here I identify critical components of a chemical hazard assessment that reflect the best available science and the recommendations of the National Academies. These elements should be a part of EPA’s chemical assessment paradigm, and included in the Chemical Safety Improvement Act (CSIA) now circulating in Congress as a reform of the outdated and inadequate Toxic Substances Control Act (TSCA).


The first task in a chemical assessment is to select the relevant studies for inclusion. Initially, selecting studies should be as comprehensive as reasonably possible, by gathering the published, unpublished, and “grey” literature (publicly available government reports, etc.) as part of the literature search.  This broad inclusive approach is generally supported by regulators, the chemical industry, and independent researchers.

Next, the scientific quality of individual studies should be determined by evaluating possible bias in the study. This can include selection bias, performance bias, attrition bias, detection bias, and reporting bias – all of which get to the heart of the “believability” of the study results. The chemical industry and the CSIA favor reporting quality as the preferred measure of study quality.[1] This favors industry-generated studies that adhere to Good Laboratory Practices (GLP). GLP is a standard for reporting and record-keeping, animal care and data collection required for industry laboratories in response to fraudulent practices documented in the 1970s. GLP is not necessarily associated with higher quality research, proper study design or correct statistical analysis.[2] Moreover, GLP studies are usually designed to identify major toxic effects like weight loss or cancer or death, rather than early-warnings of potential toxicity like genetic changes or alterations in hormone levels.  GLP studies aren’t designed to grapple with the problems of low-dose exposures, endocrine or hormonal effects, behavioral or learning effects, or reduced sperm count that predicts low fertility.

http://www.psr.org/environment-and-health/environmental-health-policy-institute/responses/use-of-best-available-science.html (more…)

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Why you should Adopt the Precautionary Principle at home (Abridged from an Article : Time to Heed the Evidence  By Sean Palfrey, MD) We can work on and pass meaningful Safe Chemical Act  reform and build in proactive responses to new evidence of medical danger whenever it appears which can stop jeopardizing the health of our children’s grandchildren. Abridged from an Article : Time to Heed the Evidence  By Sean Palfrey, MDTwo generations ago, Rachel Carson woke us up, and her book and others sounded a clarion call that should have changed the country’s laissez faire attitude about inventing, using, and discarding chemicals into our air, water, and soil before we studied them to reassure ourselves that they were harmless


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