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Archive for the ‘Treatments homeopathic’ Category

“Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts” by team of researchers headed by Yankel Gabet, DMD, PhD, Bone Research Laboratory, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. E-mail: yankel@tauex.tau.ac.il

A new study published in the Journal of Bone and Mineral Research says that a component of marijuana known as Cannabidiol (CBD) “significantly helps heal bone fractures” by speeding up the process. It also strengthens bones, protecting them against future injuries.
This research could lead to new treatment options for people suffering from certain bone-related diseases, including osteoporosis, which causes 8.9 million fractures annually across the world, according to the International Osteoporosis Foundation.

The team of researchers at Tel Aviv University tested the effect of THC and CBD separately on rat subjects, discovering a connection between our bodies’ cannabinoid receptors and bone growth stimulation. (more…)

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When conventional cancer medicine fails to produce positive outcomes, a humble little seed comes to the rescue by Sayer Ji,  founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.

A new study published in the International Journal of Oncology illustrates an important shift occurring in medical research today, namely, a growing recognition that conventional treatments like chemotherapy, taken alone, are failing to produce positive results and that the use of natural substances may be an indispensable way to improve outcomes.

In the study titled, Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines, Italian researchers sought to evaluate the possible synergistic role of an extract of flaxseed in combination with the conventional chemo-drug doxorubicin in a number of breast cancer cell lines. https://www.ncbi.nlm.nih.gov/pubmed/28101573

Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side‑effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF‑7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro‑oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.

They also noted that a commonly used cancer drug known as doxorubicin is notorious for its many side effects. You can review the primary literature on dozens of doxorubicin’s known side effects on our database. The researchers hypothesized that one way around this problem would be to reduce the amount of doxorubicin used by combining it with a safer, more natural compound.

In a previous study, the researchers showed a phenolic extract of flaxseed oil resulted in a number of chemotherapeutic effects (increase in apoptosis, G0/G1 phase cell cycle, and the activation of signaling and pro‑oxidant pathways). The new study looked at the combined effect of doxorubicin and a phenolic extract of flaxseed oil on two different breast cancer cell lines, focusing on what conditions are ideal for using lower doses doxorubicin. They reported the experiment a success:

“We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.”

While this only a preliminary investigation, and does not have the gravitas of a human clinical trial, flaxseed has been subject to extensive research on its chemopreventive and chemotherapeutic properties. We’re reported on this in depth in previous articles, such as:

We have also done a lot of advocacy around the topic of conventional treatment failure, including the problems of cancer overdiagnosis, overtreatment, and the failure of modern oncology to address the root causes of cancer and the role that cancer stem cells play in the process of carcinogenesis and treatment failure.

There is a profound shift occurring in the medical research community today. With the growing awareness that food is not just a source of energy and material building blocks for the body, but capable of being a form of medicinal or nutrigenomic information, it is no longer considered far fetched to look at something as commonplace, and benign as flaxseed as having disease-resolving power.

For more information on natural substances that may be of value in the prevention and treatment of cancer. Use our Cancer database on the topic to search thousands of studies.

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Restoration of Function With Acupuncture Following Severe Traumatic Brain Injury: A Case Report

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653595/

This case report illustrates the improvement of an acupuncture-treated patient who incurred a severe traumatic brain injury (TBI) from a snowboarding accident. Over 4 years, the patient progressed from initially not being able to walk, having difficulty with speech, and suffering from poor eyesight to where he has now regained significant motor function, speech, and vision and has returned to snowboarding. A core acupuncture protocol plus specific points added to address the patient’s ongoing concerns was used. This case adds to the medical literature by demonstrating the potential role of acupuncture in TBI treatment.
(more…)

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New Technique Successfully Dissolves Blood Clots in the Brain and Lowers Risk of Brain Damage After Stroke
CT-guided catheters carry clot-busting drug to shrink clots, Johns Hopkins-led study shows.

http://www.hopkinsmedicine.org/news/media/releases/new_technique_successfully_dissolves_blood_clots_in_the_brain_and_lowers_risk_of_brain_damage_after_stroke

Johns Hopkins neurologists report success with a new means of getting rid of potentially lethal blood clots in the brain safely without cutting through easily damaged brain tissue or removing large pieces of skull. The minimally invasive treatment, they report, increased the number of patients with intracerebral hemorrhage (ICH) who could function independently by 10 to 15 percent six months following the procedure.

The new study was coordinated by Johns Hopkins and the surgical review centers at the University of Cincinnati and the University of Chicago. All 93 patients were diagnosed with ICH, a particularly lethal or debilitating form of stroke long considered surgically untreatable under most circumstances.

“The last untreatable form of stroke may well have a treatment,” says study leader Daniel F. Hanley, M.D., a professor of neurology at the Johns Hopkins University School of Medicine. “If a larger study proves our findings correct, we may substantially reduce the burden of strokes for patients and their families by increasing the number of people who can be independent again after suffering a stroke.”

ICH is a bleed in the brain that causes a clot to form, often caused by uncontrolled high blood pressure. The clot builds up pressure and leaches inflammatory chemicals that can cause irreversible brain damage, often leading to death or extreme disability. The standard of care for ICH patients is general supportive care, usually in an ICU; only 10 percent undergo the more invasive and risky craniotomy surgery, which involves removing a portion of the skull and making incisions through healthy brain tissue to reach and remove the clot. Roughly 50 percent of people who suffer an intracerebral hemorrhage die from it. For more information:

http://www.hopkinsmedicine.org/profiles/results/directory/profile/0001943/daniel-hanley?firstLetter=H

http://www.hopkinsmedicine.org/neurology_neurosurger

(more…)

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Cannabinoids and gliomas. Velasco G, Carracedo A, Blázquez C, Lorente M, Aguado T, Haro A, Sánchez C, Galve-Roperh I, Guzmán M. https://www.ncbi.nlm.nih.gov/pubmed/17952650

Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances–the endocannabinoids–that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor cells, including glioma cells, in laboratory animals.

They do so by modulating key cell signaling pathways, mostly the endoplasmic reticulum stress response, thereby inducing antitumoral actions such as the apoptotic death of tumor cells and the inhibition of tumor angiogenesis. Of interest, cannabinoids seem to be selective antitumoral compounds, as they kill glioma cells, but not their non-transformed astroglial counterparts.

On the basis of these preclinical findings, a pilot clinical study of Delta(9)-tetrahydrocannabinol (THC) in patients with recurrent glioblastoma multiforme has been recently run. The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids.

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Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells.

https://www.ncbi.nlm.nih.gov/pubmed/27918106

Rajan TS, Giacoppo S, Scionti D Diomede F, Grassi G, Pollastro F, Piattelli A, Bramanti P Mazzon E, Trubiani O

In the last years, mesenchymal stromal cells (MSCs) from oral tissues have received considerable interest in regenerative medicine since they can be obtained with minimal invasive procedure and exhibit immunomodulatory properties. “From our results we hypothesize that human gingiva-derived MSCs conditioned with CBD could represent a valid method for improving the hGMSCs phenotype and thus might be a potential therapeutic tool in the treatment of neurodegenerative diseases.”

This study was aimed to investigate whether in vitro pre-treatment of MSCs obtained from human gingiva (hGMSCs) with Cannabidiol (CBD), a cannabinoid component produced by the plant Cannabis sativa, may promote human gingiva derived MSCs to differentiate towards neuronal precursor cells.

Specifically, we have treated the hGMSCs with CBD (5µM) for 24 h in order to evaluate theexpression of genes involved in cannabidiol signaling, cell proliferation, self-renewal and multipotency, and neural progenitor cells differentiation.

Next generation sequencing (NGS) demonstrated that CBD activates genes associated with G protein coupled receptor signaling in hGMSCs. Genes involved in DNA replication, cell cycle, proliferation and apoptosis were regulated. Moreover, genes associated with the biological process of neuronal progenitor cells (NCPs) proliferation, neuron differentiation, neurogenesis and nervous system development were significantly modulated.

From our results we hypothesize that human gingiva-derived MSCs conditioned with CBD could represent a valid method for improving the hGMSCs phenotype and thus might be a potential therapeutic tool in the treatment of neurodegenerative diseases.

https://www.ncbi.nlm.nih.gov/pubmed/27918106

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Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.
Gupta P1, Wright SE2, Kim SH3, Srivastava SK4. https://www.ncbi.nlm.nih.gov/pubmed/25152445
Abstract
The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present. Phenethyl isothiocyanate (PEITC) is present as gluconasturtiin in many cruciferous vegetables with remarkable anti-cancer effects. PEITC is known to not only prevent the initiation phase of carcinogenesis process but also to inhibit the progression of tumorigenesis. PEITC targets multiple proteins to suppress various cancer-promoting mechanisms such as cell proliferation, progression and metastasis. Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. Based on accumulating evidence, PEITC appears to be a promising agent for cancer therapy and is already under clinical trials for leukemia and lung cancer. This is the first review which provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of PEITC as a future anti-cancer agent.
Copyright © 2014 Elsevier B.V. All rights reserved.

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