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The herbicide glyphosate and the insecticides malathion and diazinon were classified as probably carcinogenic to humans. .The insecticides tetrachlorvinphos and parathion were classified as possibly carcinogenic to humans(Group 2B)IARC Monographs Volume 112: evaluation of five organophosphate insecticides and herbicidesLyon, France, 20 March 2015 – The International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization, has assessed the carcinogenicity of five organophosphate pesticides.

A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology, and the detailed assessments will be published as Volume 112 of the IARC Monographs.What were the results of the IARC evaluations Continue Reading »

Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate

Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro. The Working Group classified glyphosate as “probably carcinogenic to humans”

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2815%2970134-8/fulltext

In March, 2015, 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of the organophosphate pesticides tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans. Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro.

One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations.16 Bacterial mutagenesis tests were negative. Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro. The Working Group classified glyphosate as “probably carcinogenic to humans”

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Pesticide Exposure in Children From the American Academy of Pediatrics

http://pediatrics.aappublications.org/content/130/6/e1757.full?sid=d43469e2-b785-478e-a047-0aca6a061514

This statement presents the position of the American Academy of Pediatrics on pesticides.  “Three overarching principles can be identified: (1) pesticide exposures are common and cause both acute and chronic effects; (2) pediatricians need to be knowledgeable in pesticide identification, counseling, and management; and (3) governmental actions to improve pesticide safety are needed”

Pesticides are a collective term for chemicals intended to kill unwanted insects, plants, molds, and rodents. Children encounter pesticides daily and have unique susceptibilities to their potential toxicity. Acute poisoning risks are clear, and understanding of chronic health implications from both acute and chronic exposure are emerging. Epidemiologic evidence demonstrates associations between early life exposure to pesticides and pediatric cancers, decreased cognitive function, and behavioral problems. Related animal toxicology studies provide supportive biological plausibility for these findings. Recognizing and reducing problematic exposures will require attention to current inadequacies in medical training, public health tracking, and regulatory action on pesticides. Ongoing research describing toxicologic vulnerabilities and exposure factors across the life span are needed to inform regulatory needs and appropriate interventions. Policies that promote integrated pest management, comprehensive pesticide labeling, and marketing practices that incorporate child health considerations will enhance safe use. Continue Reading »

HUMAN HEALTH RISK ASSESSMENT FOR ALUMINIUM, ALUMINIUM OXIDE, AND ALUMINIUM HYDROXIDE http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782734/pdf/nihms33559.pdf

Aluminum and Alzheimer’s Disease –  Effects on Laboratory Mammals and In Vitro Test Systems, Neurotoxicity, Alzheimer’s Disease, studies reported aluminium may affect levels of cholesterol, which has been suggested in numerous studies as a potential modulator or Alzheimer-type amyloid formation.

Aluminum and Dementia: In a study of 20 AD subjects aged 65 to 76 , the blood aluminium was significantly greater at 60 minutes than in control subjects (104 vs. 38 μg/L).In the older subjects, the increase in blood aluminium levels was greater, but not statistically different, in the controls than in patients, in contrast to the younger subjects.  Based on greater serum and urine aluminium patients with dementia appear to absorb more aluminium from the diet than healthy subjects. 

Gilbert-Barness et al. (1998) reported the case of a 9-year-old female who was found not to be progressing developmentally at the age of 2 months. At the age of 4 months the child was diagnosed with a neurodegenerative disorder with severe mental retardation. The patient’s condition progressively worsened, resulting in death at the age of 9 years. Autopsy revealed CNS cortical atrophy, small basal ganglia, and hypomyelination of the spinal cord, cerebral cortex, subcortex and cerebellar white matter.  Following autopsy it was discovered that the mother had taken an average of 75 Maalox® tablets (containing 200 mg of aluminium hydroxide per tablet) each day during the pregnancy. These results suggested that the high levels of aluminium intake by the mother, during critical periods of the foetus’ brain development, resulted in neurological damage to the infant.

 

Increased oral aluminium absorption has been suggested in Alzheimer’s disease (AD) and Down’s subjects.  Continue Reading »

While many scientists, researchers and parents continue to look for the “smoking gun” behind the new childhood epidemics, there is “scientifically” no singular cause. Instead, many variables associated with living in modern industrial society seem to be working in concert to weaken our children’s immune systems. It is a perfect storm of genetic, epigenetic, and environmental factors that affect each child uniquely. There are simply too many sick children to substantiate the theory that genetics cause their illnesses. Epidemics of “neuro-developmental dysfunction “are not always genetic.

http://www.epidemicanswers.org/epidemic/root-causes/  Continue Reading »

According to the U.S. Centers for Disease Control and Prevention, about 1.8 million more children in the U.S. were diagnosed with developmental disabilities between 2006 and 2008 than a decade earlier. During this time, the prevalence of autism climbed nearly 300 percent, while that of attention deficit hyperactivity disorder increased 33 percent. CDC figures also show that 10 to 15 percent of all babies born in the U.S. have some type of neurobehavorial development disorder. Still more are affected by neurological disorders that don’t rise to the level of clinical diagnosis.

CDC Summary Health Statistics for U.S. Children: National Health Interview Survey, 2009

http://www.cdc.gov/nchs/data/series/sr_10/sr10_247.pdf

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Observed associations in humans and direct effects on neurodevelopmental toxicity in animal studies, caution is warranted for women to avoid direct contact with pesticides during pregnancy. 

Two new ground breaking peer reviewed published research articles now link certain childhood neuro – developmental disorders to prenatal residential exposure to two classes of widely used toxic pesticides,.

Specifically the research found that applications of two of the most commonly used agricultural and residentially applied pesticides namely organophosphates and pyrethroids near the home may increase the prevalence of ASD in early childhood Continue Reading »

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