The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Abstract CD47, a “don’t eat me” signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer
http://www.pnas.org/content/109/17/6662