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Archive for March, 2014

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Abstract CD47, a “don’t eat me” signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer

http://www.pnas.org/content/109/17/6662

http://www.pnas.org/content/suppl/2012/03/20/1121623109.DCSupplemental/pnas.201121623SI.pdf
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Glyphosate, Hard Water and Nephrotoxic Metals: Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka?  http://www.mdpi.com/1660-4601/11/2/2125

Although glyphosate alone does not cause an epidemic of chronic kidney disease, it seems to have acquired the ability to destroy the renal tissues of thousands of farmers when it forms complexes with a localized geo environmental factor (hardness) and nephrotoxic metals.

Channa Jayasumana 1,2,emailSarath Gunatilake 2,†email and Priyantha Senanayake 3,†email 1 Department of Pharmacology, Faculty of Medicine, Rajarata University, Anuradhapura 50008, Sri Lanka2 Health Science Department, California State University, Long Beach, CA 90840, USA3 Hela Suwaya Organization, Malabe 10115, Sri Lanka  (more…)

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Glyphosate/Roundup & Human Male Infertility

http://www.i-sis.org.uk/Glyphosate_Roundup_and_Human_Male_Infertility.php

 Steep decline in human male sperm count concomitant with rise in testicular germ cell cancer, congenital malformations of the male reproductive tract and drop in serum testosterone levels, all pointing towards increasing exposure to glyphosate/Roundup herbicides during the past decades, now corroborated by lab findings by Dr Mae-Wan Ho 

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Detection of Glyphosate Residues found  in Animals and Humans “Presence of glyphosate in urine and its accumulation in animal tissues is alarming even at low concentrations. Unknown impacts of glyphosate on human and animal health warrants further investigations of glyphosate residues in vertebrates and other non-target organisms.”

http://omicsonline.org/open-access/detection-of-glyphosate-residues-in-animals-and-humans-2161-0525.1000210.pdf

Detection of Glyphosate Residues found  in Animals and Humans Monika Krüger1, Philipp Schledorn1, Wieland Schrödl1, Hans-Wolfgang Hoppe2, Walburga Lutz3 and Awad A. Shehata1,4*

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Identification of infants at risk for autism spectrum disorder and developmental language delay prior to 12 months. Samango-Sprouse CA1, Stapleton EJAliabadi FGraw RVickers RHaskell KSadeghin TJameson RParmele CLGropman AL.

This study demonstrates an efficient means to identify infants at risk for autism spectrum disorder by 9 months of age and serves to alert primary care providers of infants who are vulnerable for autism spectrum disorder before symptoms are discernible by clinical judgment of primary care providers, parental concerns, or by screening questionnaires.

Identification of infants at risk for autism spectrum disorder and developmental language delay prior to 12 months. Samango-Sprouse CA1, Stapleton EJAliabadi FGraw RVickers RHaskell KSadeghin TJameson RParmele CLGropman AL.http://www.ncbi.nlm.nih.gov/pubmed/24550549

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The Gut Microbiome and Cancer . Our gut microbiota influence cancer susceptibility of our digestive tract as well as distant organs including the skin, lungs, breasts and liver Dr Eva Sirinathsinghji http://www.i-sis.org.uk/The_Gut_Microbiome_and_Cancer.php

Cancer is a leading disease in industrialised nations and the incidence is rising sharply in developing nations as a result of aging demographics, “westernised” diets, exposure to chemical carcinogens and inactivity. Though there are genetic causes for certain cancers that give a significant risk to the individual carrier e.g. BRCA1 mutations and breast cancer, most cancers are linked to environmental factors. Despite this overriding environmental determinant in cancer susceptibility, we still know relatively little about the environmental factors involved. Recent research on the gut microbiota reveals a complex and important role that this ‘forgotten organ’ may play, not only in preventing or promoting carcinogenesis, but also in modifiying the efficacy of different therapies.  

fully referenced version of this article is posted on ISIS members website and is otherwise available for download here

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Studies on Bisphenol A (BPA) and Health Effects. From Rochester JR, Bisphenol A and Human Health: A review of the literature, Reproductive Toxicology (2013 in press).

TEDX releases a comprehensive review of the human health effects of bisphenol A

A comprehensive review conducted by TEDX’s Johanna Rochester, PhD, was recently accepted for publication in Reproductive Toxicology.
Associations were revealed between bisphenol A (BPA) exposure and adverse perinatal, childhood and adult health outcomes in humans, including reproductive and developmental effects, metabolic disease and other health outcomes, particularly behavioral effects in children.
These studies, over half of which were published in the last year, confirm that BPA can be harmful to humans at levels experienced by the general population, and well below levels considered safe by the USEPA.
Click here to read the abstract and download a pdf of the submitted manuscript.
More information on endocrine disrupting chemicals can be found at www.endocrinedisruption.org.

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